Nanoarchitectonics of Indocyanine Green/Doxorubicin-Loaded Hydroxyl Boron Nitride Nanosheets for Chemophotothermal Therapy.
Ming LiuChiyu SunShuangyan WuMingchang ZhuYing ZhangPublished in: ChemPlusChem (2022)
Biocompatible hydroxylated boron nitride nanosheets were effectively loaded with indocyanine green and doxorubicin using successive assembly. The indocyanine green/doxorubicin-loaded hydroxyl boron nitride nanosheets (ICG/DOX@OH-BNNS) integrated photothermal therapy and chemotherapy into a single nano vehicle. It had been confirmed that ICG/DOX@OH-BNNS could produce reactive oxygen species and exhibit excellent photothermal effects and light-triggered faster DOX release with NIR laser irradiation. On the other hand, the fluorescence of DOX in ICG/DOX@OH-BNNS was also used for visualizing subcellular location. Compared with individual chemotherapy and photothermal therapy, the combined treatment of ICG/DOX@OH-BNNS could synergistically induce the apoptosis and death of A549 cells and suppress S180 tumor growth in vivo.
Keyphrases
- drug delivery
- cancer therapy
- fluorescence imaging
- quantum dots
- reduced graphene oxide
- drug release
- visible light
- photodynamic therapy
- cell cycle arrest
- reactive oxygen species
- induced apoptosis
- locally advanced
- endoplasmic reticulum stress
- cell death
- gold nanoparticles
- oxidative stress
- metal organic framework
- wound healing
- squamous cell carcinoma
- stem cells
- energy transfer
- single molecule
- high speed
- mesenchymal stem cells
- cell proliferation
- ionic liquid
- bone marrow