The pro-apoptotic Bax gene modifies susceptibility to craniofacial dysmorphology following gastrulation-stage alcohol exposure.

Eric W Fish Haley N Mendoza-RomeroCharlotte A LoveConstance J DragicevichMichael D CannizzoKaren E BoschenAustin HepperlaJeremy M SimonScott E Parnell

Published in: Birth defects research (2022)

Overall, these experiments identify that Bax is a primary teratogenic mechanism of gastrulation-stage alcohol exposure.

Keyphrases

anti inflammatory
cell death
induced apoptosis
alcohol consumption
genome wide
copy number
gene expression
signaling pathway
endoplasmic reticulum stress
transcription factor