Ultra-selective, ultra-clean 1D rotating-frame Overhauser effect spectroscopy.
Emma L GatesMarshall J SmithJonathan P BradleyMyron JohnsonGöran WidmalmMathias NilssonGareth A MorrisRalph W AdamsLaura CastañarPublished in: Chemical communications (Cambridge, England) (2023)
An ultra-selective 1D NMR experiment - GEMSTONE-ROESY - enables clear, unambiguous assignment of ROE signals in the not uncommon situation that traditional selective methods fail. Its usefulness is demonstrated in the analysis of the natural products cyclosporin and lacto- N -difucohexaose I, providing detailed insight into the structures and conformations of these molecules.