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Engineered anti-EGFRvIII targeted exosomes induce apoptosis in glioblastoma multiforme.

Rana RahmaniJafar KianiWing Yin TongMasoud SoleimaniNicolas H VoelckerEhsan Arefian
Published in: Journal of drug targeting (2022)
The experimental findings clearly show the improved apoptosis rate of GBM cells when treated by engineered exosomes armed with two gene therapy agents and targeted toward EGFRvIII antigen.
Keyphrases
  • cell cycle arrest
  • gene therapy
  • cell death
  • endoplasmic reticulum stress
  • induced apoptosis
  • pi k akt
  • mesenchymal stem cells
  • oxidative stress
  • stem cells
  • cancer therapy
  • drug delivery
  • cell proliferation