Confirmed Fatal Colchicine Poisoning in an Adolescent with Blood and Bile Concentrations-Implications for GI Decontamination?
Joshua D TrebachMolly BoydAndres CranePhil DiSalvoRana BiaryRobert S HoffmanMark K SuPublished in: Journal of medical toxicology : official journal of the American College of Medical Toxicology (2023)
Despite supportive care, activated charcoal, VA-ECMO, and exchange transfusion, modern medicine may not be enough to prevent death in severely poisoned colchicine patients. Although targeting enterohepatic circulation with activated charcoal to enhance elimination of colchicine sounds attractive, the patient's low postmortem bile concentration of colchicine suggests a limited role of activated charcoal in enhancing elimination of a consequential amount of colchicine.
Keyphrases
- end stage renal disease
- newly diagnosed
- healthcare
- chronic kidney disease
- ejection fraction
- mental health
- palliative care
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- case report
- prognostic factors
- peritoneal dialysis
- patient reported outcomes
- cancer therapy
- health insurance
- respiratory failure