Young Breast Cancer: Novel Gene Methylation in WBC.
Mehrdad NoruziniaJavad Tavakkoly-BazzazMohamad AhmadvandFatemeh AzimiAli DehghanifardGolnaz KhakpourPublished in: Asian Pacific journal of cancer prevention : APJCP (2021)
A total of 1799 differentially methylated regions were identified, including ZNF154, BCL9, and HOXD9, in which significant methylation differences were confirmed in breast cancer patients through a quantitative real-time polymerase chain reaction. Differential methylation of the mentioned genes has been reported in different cancer tissues and cell-free DNA, including breast cancer. Methylation of those genes listed in the white blood cells of our young patients not only relates to their importance in the pathogenesis of breast cancer but may also highlight their potential as primary epimarkers that can warrant further evaluation in large cohort studies. It is important to note that methylation alteration in WBC, as well as genetic mutation, can be identified years before cancer development, which emphasizes this issue as a potential screening marker.
Keyphrases
- real time pcr
- genome wide
- dna methylation
- papillary thyroid
- copy number
- end stage renal disease
- gene expression
- squamous cell
- induced apoptosis
- childhood cancer
- chronic kidney disease
- prognostic factors
- middle aged
- genome wide identification
- lymph node metastasis
- oxidative stress
- young adults
- signaling pathway
- climate change