Interactions Between Genetic Risk and Diet Influencing Risk of Incident Female Gout: Discovery and Replication Analysis of Four Prospective Cohorts.

Kehuan Lin Natalie McCormick Chio YokoseAmit D JoshiNa LuGary C CurhanTony Raymond MerrimanKenneth G SaagPaul M RidkerJulie E BuringDaniel I ChasmanFrank B HuHyon K Choi

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

The deleterious effect of genetic predisposition on risk of incident female gout was more pronounced among women with unhealthy diet, with nearly half the excess risk attributable to this gene-diet interaction. These data elucidate the important synergy of genetics and diet for female gout development. This article is protected by copyright. All rights reserved.

Keyphrases

weight loss
physical activity
uric acid
genome wide
cardiovascular disease
copy number
metabolic syndrome
high throughput