Intrarenal Renin-Angiotensin System Activation Alters Relationship Between Systolic Blood Pressure and Progression of Chronic Kidney Disease.
Cheol Ho ParkHyung Woo KimJung Tak ParkTae Ik ChangTae-Hyun YooJoongyub LeeSu Ah SungJi Yong JungYoung Youl HyunKook-Hwan OhShin-Wook KangSeung-Hyeok Hannull nullPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
In this prospective CKD cohort, higher SBP was associated with CKD progression when urinary angiotensinogen levels were low, while this association was not seen when urinary angiotensinogen levels were high. This finding suggests that intrarenal renin-angiotensin system activity may modify the relationship between SBP and adverse kidney outcome.