ABCC6 Deficiency Promotes Development of Randall Plaque.
Emmanuel LetavernierGilles KauffensteinLéa HuguetNastassia NavasiolavaElise BouderliqueEllie TangLéa DelaitreDominique BazinMarta de FrutosClément GayJoëlle PerezMarie-Christine VerpontJean-Philippe HaymannViola PomoziJanna ZollOlivier Le SauxMichel DaudonGeorges LeftheriotisLudovic MartinPublished in: Journal of the American Society of Nephrology : JASN (2018)
The frequency of kidney stones and probably, Randall plaque is extremely high in patients with PXE, and Abcc6-/- mice provide a new and useful model in which to study Randall plaque formation. Our findings also suggest that pyrophosphate administration should be evaluated for the prevention of Randall plaque and kidney stones.