White-Light-Responsive Prussian Blue Nanophotonic Particles for Effective Eradication of Bacteria and Improved Healing of Infected Cutaneous Wounds.
Nayanika ChakrabortyDiksha JhaVijay Pal SinghPradeep KumarNavin Kumar VermaHemant Kumar GautamIndrajit RoyPublished in: ACS applied materials & interfaces (2023)
The increasing burden of cutaneous wound infections with drug-resistant bacteria underlines the dire need for novel treatment approaches. Here, we report the preparation steps, characterization, and antibacterial efficacy of novel chitosan-coated Prussian blue nanoparticles loaded with the photosensitizer fluorescein isothiocyanate-dextran (CHPB-FD). With excellent photothermal and photodynamic properties, CHPB-FD nanoparticles can effectively eradicate both Gram-positive methicillin-resistant Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa in vitro and in vivo . The antibacterial efficacy of CHPB-FD nanophotonic particles further increases in the presence of white light. Using a bacteria-infected cutaneous wound rat model, we demonstrate that CHPB-FD particles upregulate genes involved in tissue remodeling, promote collagen deposition, reduce unwanted inflammation, and enhance healing. The light-responsive CHPB-FD nanophotonic particles can, therefore, be potentially used as an economical and safe alternative to antibiotics for effectively decontaminating skin wounds and for disinfecting biomedical equipment and surfaces in hospitals and other places.
Keyphrases
- wound healing
- gram negative
- multidrug resistant
- drug resistant
- cancer therapy
- methicillin resistant staphylococcus aureus
- acinetobacter baumannii
- drug delivery
- pseudomonas aeruginosa
- photodynamic therapy
- staphylococcus aureus
- cystic fibrosis
- oxidative stress
- healthcare
- biofilm formation
- silver nanoparticles
- escherichia coli
- helicobacter pylori
- drug release
- combination therapy
- mass spectrometry
- helicobacter pylori infection
- smoking cessation
- soft tissue