sST2 as a novel biomarker for the prediction of in-hospital mortality after coronary artery bypass grafting.
Meagan E StablerMichael E RezaeeDevin M ParkerTodd A MacKenzieAndrew R BohmAnthony W DiScipioDavid J MalenkaJeremiah R BrownPublished in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2019)
Objectives: Soluble suppression of tumorigenicity 2 (sST2) biomarker is an emerging predictor of adverse clinical outcomes, but its prognostic value for in-hospital mortality after coronary artery bypass grafting (CABG) is not well understood. This study measured the association between operative sST2 levels and in-hospital mortality after CABG. Methods: A prospective cohort of 1560 CABG patients were analyzed from the Northern New England Cardiovascular Disease Study Group Biomarker Study. The primary outcome was in-hospital mortality after CABG surgery (n = 32). Results: After risk adjustment, patients in the third tercile of pre-, post- and pre-to-postoperative sST2 values experienced significantly greater odds of in-hospital death compared to patients in the first tercile of sST2 values. The addition of both postoperative and pre-to-postoperative sST2 biomarker significantly improved ability to predict in-hospital mortality status following CABG surgery, compared to using the EuroSCORE II mortality model alone, (c-statistic: 0.83 [95% CI: 0.75, 0.92], p value 0.0213) and (c-statistic: 0.83 [95% CI: 0.75, 0.92], p value 0.0215), respectively. Conclusion: sST2 values are associated with in-hospital mortality after CABG surgery and postoperative and pre-to-post operative sST2 values improve prediction. Our findings suggest that sST2 can be used as a biomarker to identify adult patients at greatest risk of in-hospital death after CABG surgery.
Keyphrases
- coronary artery bypass grafting
- coronary artery bypass
- percutaneous coronary intervention
- coronary artery disease
- minimally invasive
- cardiovascular disease
- healthcare
- end stage renal disease
- ejection fraction
- newly diagnosed
- acute care
- adverse drug
- prognostic factors
- type diabetes
- emergency department
- patient reported outcomes
- young adults
- cardiovascular events
- atrial fibrillation
- risk factors
- cardiovascular risk factors