Identification of MALDI Imaging Proteolytic Peptides Using LC-MS/MS-Based Biomarker Discovery Data: A Proof of Concept.

Rémi LonguespéeAlice LyRita CasadonteKristina SchwambornDaniel KazdalChristiane ZgorzelskiChristine BollweinKatharina KriegsmannWilko WeichertJörg KriegsmannPeter SchirmacherMargaux FresnaisCristiano OliveiraMark Kriegsmann

Published in: Proteomics. Clinical applications (2018)

This concept combines LC-MS/MS-based quantitative proteomics with MALDI imaging and allows reliable peptide identification. Public datasets from LC-MS/MS biomarker discovery experiments will be useful to identify MALDI imaging m/z peaks.

Keyphrases

mass spectrometry
high resolution
small molecule
emergency department
electronic health record
bioinformatics analysis
rna seq
photodynamic therapy