Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia.

Natanja OosteromRobert de JongeDesiree E C SmithRob PietersWim J E TissingMarta FioccoBertrand D van ZelstMarry M van den Heuvel-EibrinkSandra G Heil

Published in: PloS one (2019)

Intracellular folate levels accumulate after HD-MTX and Leucovorin therapy in children with ALL, suggesting that Leucovorin restores the intracellular folate pool. Future studies are necessary to assess concomitant lower uptake of MTX.

Keyphrases

high dose
acute lymphoblastic leukemia
young adults
reactive oxygen species
low dose
stem cell transplantation
allogeneic hematopoietic stem cell transplantation
current status
case control
bone marrow