Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer's Disease and CNS-Related Disorders.
Athanasios AlexiouGeorgia SoursouStylianos ChatzichronisErmis GasparatosMohammad Amjad KamalNagendra Sastry YarlaAsma PerveenGeorge E BarretoGhulam Md AshrafPublished in: Molecular neurobiology (2018)
Data obtained from several studies have shown that mitochondria are involved and play a central role in the progression of several distinct pathological conditions. Morphological alterations and disruptions on the functionality of mitochondria may be related to metabolic and energy deficiency in neurons in a neurodegenerative disorder. Several recent studies demonstrate the linkage between neurodegeneration and mitochondrial dynamics in the spectrum of a promising era called precision mitochondrial medicine. In this review paper, an analysis of the correlation between mitochondria, Alzheimer's disease, and other central nervous system (CNS)-related disorders like the Parkinson's disease and the autism spectrum disorder is under discussion. The role of GTPases like the mfn1, mfn2, opa1, and dlp1 in mitochondrial fission and fusion is also under investigation, influencing mitochondrial population and leading to oxidative stress and neuronal damage.
Keyphrases
- oxidative stress
- autism spectrum disorder
- ischemia reperfusion injury
- cell death
- diabetic rats
- reactive oxygen species
- cognitive decline
- induced apoptosis
- blood brain barrier
- endoplasmic reticulum
- attention deficit hyperactivity disorder
- gene expression
- dna methylation
- deep learning
- drug induced
- case control
- subarachnoid hemorrhage
- hiv infected
- replacement therapy
- antiretroviral therapy
- high density