Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice.
Shingo TakashimaFumio TanakaYunosuke KawaguchiYuki UsuiKosuke FujimotoYuji NadataniKoji OtaniShuhei HosomiYasuaki NagamiNoriko KamataKoichi TairaTetsuya TanigawaToshio WatanabeSeiya ImotoSatoshi UematsuYasuhiro FujiwaraPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
Under stressed conditions, PPI enhances intestinal permeability via dysbiosis of gut microbiota. Vasoactive intestinal peptide and mast cells are also implicated in the underlying mechanisms.
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