Evaluation of pharmacogenomics and hepatic nuclear imaging-related covariates by population pharmacokinetic models of irinotecan and its metabolites.

Zheng LiuJennifer H MartinWinston LiauwSue-Anne McLachlanEmma LinkAnetta MateraMichael ThompsonMichael JeffordRod J HicksCarleen CullinaneAthena HatzimihalisIan CampbellSimone CrowleyPhillip J BealeChristos S KarapetisTimothy PriceMathew E BurgeMichael Michael

Published in: European journal of clinical pharmacology (2021)

The identified UGT1A3_c.31 T > C and ABCB1_c.3435C > T variants, from wild type to homozygous, were included in the final model for SN38 clearance.

Keyphrases

wild type
high resolution
ms ms
copy number
clinical decision support
emergency department
gene expression
fluorescence imaging