Thromboelastography and thrombin generation assessments for pediatric severe hemophilia A patients are highly variable and not predictive of clinical phenotypes.

Natalie Mathews Fred G Pluthero Margaret L RandAnn Marie StainManuel D Carcao Victor S Blanchette Walter H A Kahr

Published in: Research and practice in thrombosis and haemostasis (2022)

hemostatic assay results of samples containing platelets showed concordance. Assay results were not predictive of FVIII requirements or correlated with other clinical parameters. SHA patient heterogeneity is influenced by factors other than baseline hemostatic activity.

Keyphrases

end stage renal disease
high throughput
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
case report
single cell
early onset