Semaglutide Improves Myocardial Perfusion and Performance in a Large Animal Model of Coronary Artery Disease.
Christopher R StoneDwight D HarrisMark BroadwinMeghamsh KanuparthyJu-Woo NhoKeertana YalamanchiliJad HamzeM Ruhul AbidFrank W SellkePublished in: bioRxiv : the preprint server for biology (2024)
This study is the first to reveal the capacity of oral semaglutide to augment cardiac function in the chronically ischemic heart in a highly translational large animal model, likely through AMPK-mediated improvement in endothelial function and perfusion to the ischemic myocardium.
Keyphrases
- coronary artery disease
- ischemia reperfusion injury
- heart failure
- skeletal muscle
- cerebral ischemia
- percutaneous coronary intervention
- genome wide
- cardiovascular events
- single cell
- gene expression
- atrial fibrillation
- cardiovascular disease
- type diabetes
- magnetic resonance
- contrast enhanced
- acute coronary syndrome
- protein kinase
- blood brain barrier