Immunoglobulin G of systemic sclerosis patients programs a pro-inflammatory and profibrotic phenotype in monocyte-like THP-1 cells.
Sripriya MurthyMelanie WannickGeorgios EleftheriadisAntje MüllerJiao LuoHauke BuschAnja DalmannGabriela RiemekastenChristian D SadikPublished in: Rheumatology (Oxford, England) (2021)
Our results suggest that SSc-IgG contributes to the generation of the pro-inflammatory/profibrotic tissue milieu characteristic of SSc by its induction of a respective phenotype in monocytes. Furthermore, our results highlight AP-1 as a critical regulator of gene transcription of CCL18 in monocytic cells and as a promising pharmacological therapeutic target for the treatment of SSc.
Keyphrases
- systemic sclerosis
- induced apoptosis
- cell cycle arrest
- interstitial lung disease
- end stage renal disease
- transcription factor
- chronic kidney disease
- dendritic cells
- ejection fraction
- endoplasmic reticulum stress
- newly diagnosed
- peripheral blood
- public health
- signaling pathway
- pi k akt
- liver injury
- gene expression
- drug induced
- cell proliferation