Epithelial-mesenchymal transition induced by tumor cell-intrinsic PD-L1 signaling predicts a poor response to immune checkpoint inhibitors in PD-L1-high lung cancer.

Hyein JeongJaemoon KohSehui KimSeung Geun SongSoo Hyun LeeYoungjoo JeonChul-Hwan LeeBhumsuk Keam Se-Hoon LeeDoo Hyun ChungYoon Kyung Jeon

Published in: British journal of cancer (2024)

Tumor cell-intrinsic PD-L1 function contributes to NSCLC progression by promoting EMT. EMT may predict an unfavorable outcome after ICI therapy in PD-L1-high NSCLC.

Keyphrases

epithelial mesenchymal transition
small cell lung cancer
single cell
cell therapy
transforming growth factor
advanced non small cell lung cancer
signaling pathway
stem cells
epidermal growth factor receptor
smoking cessation
replacement therapy