A GWAS in Idiopathic/Unexplained Infertile Men Detects a Genomic Region Determining Follicle-Stimulating Hormone Levels.

Maria SchubertLina Pérez LanuzaMarius WösteMartin DugasFrancisco David CarmonaRogelio J Palomino-MoralesYousif RassamStefanie Heilmann-HeimbachFrank TüttelmannSabine KlieschJörg Gromoll

Published in: The Journal of clinical endocrinology and metabolism (2022)

This GWAS delineates the polymorphic FSHB genomic region as the main determinant of FSH levels in men with unexplained or idiopathic infertility. Given the essential role of FSH, molecular detection of one of the identified SNVs that causes lowered FSH and therewith decreases spermatogenesis could resolve the idiopathic/unexplained origin by this etiologic factor.

Keyphrases

copy number
polycystic ovary syndrome
middle aged
type diabetes
metabolic syndrome
adipose tissue