Infections following chimeric antigen receptor T cell therapy: 2018-2022.
Vishakh C KeriLea M MondayJahanavi M RamakrishnaRahul VyasAbhinav DeolMahmoud Al-SaadiPranatharthi H ChandrasekarPublished in: Transplant infectious disease : an official journal of the Transplantation Society (2024)
COVID-19 and C. difficile infection were the most common infections following CAR T-cell therapy. Most infections occurred within the first 100 days. Empiric antibiotic use and C. difficile infection were common in patients with CRS/ICANS, in the absence of documented bacterial infection, thus providing an excellent opportunity for antimicrobial stewardship in this population.