Melanoma Cell Membrane Biomimetic Versatile CuS Nanoprobes for Homologous Targeting Photoacoustic Imaging and Photothermal Chemotherapy.
Minliang WuTianxiao MeiChenyu LinYuchong WangJingyao ChenWenjun LeMengyan SunJianguo XuHaiying DaiYifan ZhangChunyu XueZhongmin LiuBingdi ChenPublished in: ACS applied materials & interfaces (2020)
Modulating the surface properties of nanoparticles (NPs) is an important approach to accomplish immune escape, prolonged the blood retention time, and enhance the ability of targeted drug delivery. The camouflage of cancer cell membrane onto nanoparticles has been proved to be an ideal approach to enhance active targeting ability of NPs. Herein, we isolated the membrane of melanoma cells to coat doxorubicin (DOX) and indocyanine green (ICG)-loaded hollow copper sulfide NPs (ID-HCuSNP@B16F10) for targeted photothermal therapy, photoacoustic imaging, and chemotherapy. A remarkable in vitro anticancer effect after irradiation and homologous targeting can be observed in B16F10 cells after the treatment of ID-HCuSNP@B16F10. Moreover, ID-HCuSNP@B16F10 exhibits excellent photothermal effect in melanoma animal models and achieves a high tumor ablation rate. This biomimetic system can realize high drug loading efficiency, enhanced targeting ability, and ideal antitumor efficiency.
Keyphrases
- cancer therapy
- drug delivery
- fluorescence imaging
- high resolution
- dna damage
- drug release
- photodynamic therapy
- induced apoptosis
- dna repair
- squamous cell carcinoma
- signaling pathway
- emergency department
- cell proliferation
- cell death
- squamous cell
- liquid chromatography
- molecularly imprinted
- metal organic framework
- mass spectrometry
- lymph node metastasis
- tandem mass spectrometry