Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children.
Evelien R van MeelSara M Mensink-BoutHerman T den DekkerTarunveer S AhluwaliaIsabella Annesi-MaesanoSyed Hasan ArshadNour BaïzHenrique BarrosAndrea von BergHans BisgaardKlaus BønnelykkeChristian J CarlssonMaribel CasasLeda ChatziCecile ChevrierGeertje DalmeijerCarol DezateuxKarel DuchenMerete EggesbøCornelis van der EntMaria FantiniClaudia FlexederUrs FreyFransesco ForastiereUlrike GehringDavide GoriRaquel GranellLucy J GriffithsHazel InskipJoanna JerzynskaAnne M KarvonenThomas KeilCecily KelleherManolis KogevinasGudrun KoppenClaudia Elisabeth KuehniNathalie LambrechtsSusanne LauIrina LehmannJohnny LudvigssonMaria Christine MagnusErik MelénJohn MeheganMonique MommersAnne-Marie Nybo AndersenWenche NystadEva Sophie Lunde PedersenJuha PekkanenVille PeltolaKatharine C PikeAngela Pinot de MoiraCostanza PizziKinga PolanskaMaja PopovićDaniela PortaGraham RobertsAna Cristina SantosErica S SchultzMarie StandlJordi SunyerCarel ThijsLaura ToivonenEleonora UphoffJakob UsemannMarina VafeidiJohn WrightJohan C de JongsteVincent W V JaddoeLiesbeth DuijtsPublished in: The European respiratory journal (2022)
Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections.