An individualized treatment rule to optimize probability of remission by continuation, switching, or combining antidepressant medications after failing a first-line antidepressant in a two-stage randomized trial.
Ronald C KesslerToshi A FurukawaTadashi KatoAlex LuedtkeMaria PetukhovaEkaterina SadikovaNancy A SampsonPublished in: Psychological medicine (2021)
An ITR can be developed to improve second-line antidepressant selection, but replication in a larger study with more comprehensive baseline predictors might produce stronger and more stable results.