Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease.

Hydrogen sulfide (H 2 S) has emerged as the third "gasotransmitters" and has a crucial function in the diversity of physiological functions in mammals. In particular, H 2 S is considered indispensable in preventing the development of liver inflammation in the case of excessive caloric ingestion. Note that the concentration of endogenous H 2 S was usually low, making it difficult to discern the precise biological functions. Therefore, exogenous delivery of H 2 S is conducive to probe the physiological and pathological roles of this gas in cellular and animal studies. In this review, the production and metabolic pathways of H 2 S in vivo, the types of donors currently used for H 2 S release, and study evidence of H 2 S improvement effects on nonalcoholic fatty liver disease are systematically introduced.