Cost-effectiveness of home non-invasive ventilation in patients with persistent hypercapnia after an acute exacerbation of COPD in the UK.
Patrick Brian MurphyBernd BrueggenjuergenThomas ReinholdQing GuLaura FusfeldGerard CrinerThomas F GossNicholas HartPublished in: Thorax (2023)
Home non-invasive mechanical ventilation (HMV) with home oxygen therapy (HOT) in patients with persistent hypercapnia following an acute exacerbation of chronic obstructive pulmonary disease delays hospital readmission. The economic impact of this treatment is unknown. We evaluated the cost-effectiveness of HMV in the UK healthcare system using data from a previously published efficacy trial. Quality-adjusted life-years (QALYs) were computed from EQ-5D-5L. Accounting for all direct patient costs HOT-HMV was £512 (95%CI £36 to £990) more expensive per patient per year than HOT-alone. This small increase in cost was accompanied by increased quality of life leading to an incremental cost-effectiveness ratio of £10 259 per QALY. HOT-HMV was cost-effective in this clinical population. Trial registration number: NCT00990132.
Keyphrases
- respiratory failure
- mechanical ventilation
- chronic obstructive pulmonary disease
- healthcare
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- intensive care unit
- liver failure
- case report
- phase iii
- study protocol
- clinical trial
- phase ii
- drug induced
- lung function
- quality improvement
- magnetic resonance imaging
- big data
- emergency department
- mesenchymal stem cells
- hepatitis b virus
- machine learning
- smoking cessation
- diffusion weighted imaging