Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling.
Xu CaoSong WuXinxing WangJunjie HuangWenxiu ZhangChi LiangPublished in: Molecular medicine (Cambridge, Mass.) (2023)
C-kit drives EMT signaling in OA-FLSs and promotes a destructive FLS phenotype, leading to synovial inflammation and cartilage destruction.