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Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling.

Xu CaoSong WuXinxing WangJunjie HuangWenxiu ZhangChi Liang
Published in: Molecular medicine (Cambridge, Mass.) (2023)
C-kit drives EMT signaling in OA-FLSs and promotes a destructive FLS phenotype, leading to synovial inflammation and cartilage destruction.
Keyphrases
  • tyrosine kinase
  • epithelial mesenchymal transition
  • epidermal growth factor receptor
  • knee osteoarthritis
  • oxidative stress
  • extracellular matrix
  • reactive oxygen species