Cobalt(II)-Catalyzed Intermolecular Aminocarbonylation of Indoles with Amines.

A cobalt(II)-catalyzed C2-H carbonylation of indoles with amines toward indole-2-carboxamides has been developed. By employing Co(OAc) 2 ·4H 2 O as an inexpensive catalyst and using benzene-1,3,5-triyl triformate (TFBen) as the CO surrogate, a variety of indole-2-carboxamide derivatives were produced in moderate to high yields. Additionally, several bioactive-molecule-related compounds can be applied as substrates, as well.