Risk Factors Associated with Suboptimal Tobramycin Levels in the Medical Intensive Care Unit.

Jacob P CountsJessica L ElefritzErica E ReedMarilly PalettasConnor AosseyJulia J Beatty

Published in: European journal of drug metabolism and pharmacokinetics (2022)

Among patients receiving their first dose of tobramycin in the MICU, 81.3% obtained an optimal serum concentration. Female sex and serum albumin < 2.5 g/dL were identified as risk factors for suboptimal target obtainment; however, further research is warranted to assess the utility of using these two covariates as risk factors for more aggressive dosing in critically ill MICU patients.

Keyphrases

intensive care unit
end stage renal disease
ejection fraction
newly diagnosed
healthcare
peritoneal dialysis
prognostic factors
mechanical ventilation
patient reported outcomes