Drug holiday in patients with polycystic liver disease treated with somatostatin analogues.

René M M van AertsMarieke KolkmanWietske KievitTom J G GeversFrederik NevensJoost Paulus Hubertus Drenth

Published in: Therapeutic advances in gastroenterology (2018)

PLD patients treated with SAs benefit from retreatment after a drug holiday. The significant increase of liver volume after cessation of treatment complicates widespread use of a drug holiday as new treatment strategy. Our results contribute to a better understanding of the pharmacological effect of SAs and help to identify patients who might benefit.

Keyphrases

emergency department
adverse drug
drug induced
molecular docking
neuroendocrine tumors