Diazoxide improves muscle function in association with improved dyslipidemia and decreased muscle oxidative stress in streptozotocin-induced diabetic rats.

Manuel Alejandro Vargas-VargasAlfredo Saavedra-MolinaMariana Gómez-BarrosoDonovan Peña-MontesChristian Cortés-RojoAlain R Rodríguez-OrozcoMontoya-Pérez Rocío

Published in: Journal of bioenergetics and biomembranes (2023)

Diazoxide administration in diabetic rats increases muscle strength development in EDL and soleus muscle, decreases fatigue, reduces cholesterol and triglyceride concentrations and improves oxidative stress parameters such as TBARS, ROS, and glutathione status.

Keyphrases

diabetic rats
oxidative stress
skeletal muscle
dna damage
ischemia reperfusion injury
physical activity
adipose tissue
insulin resistance
metabolic syndrome