Real-world implementation and impact of a rapid carbapenemase detection test in an area endemic for carbapenem-resistant Enterobacterales.
Alex M TrzebuckiLars F WestbladeAngela LooShawn MazurStephen G JenkinsDavid P CalfeeMichael J SatlinMatthew S SimonPublished in: Infection control and hospital epidemiology (2021)
A retrospective study was conducted to describe the impact of a molecular assay to detect the most common carbapenemase genes in carbapenem-resistant Enterobacterales isolates recovered in culture. Carbapenemases were detected in 69% of isolates, and assay results guided treatment modifications or epidemiologic investigation in 20% and 4% of cases, respectively.
Keyphrases
- klebsiella pneumoniae
- loop mediated isothermal amplification
- acinetobacter baumannii
- high throughput
- gram negative
- multidrug resistant
- healthcare
- genetic diversity
- escherichia coli
- primary care
- genome wide
- quality improvement
- drug resistant
- gene expression
- single molecule
- combination therapy
- single cell
- transcription factor
- genome wide analysis