Long-term clinical, imaging and cognitive outcomes association with MS immunopathology.

Alicja Kalinowska-LyszczarzJan-Mendelt TillemaWilliam Oliver TobinYong GuoStephen D WeigandImke MetzWolfgang BrückHans LassmannMonica Giraldo-ChicaJohn D PortClaudia F Lucchinetti

Published in: Annals of clinical and translational neurology (2023)

In this study, immunopathological heterogeneity of early-active MS lesions identified at biopsy does not correlate with different long-term clinical, neuroimaging or cognitive outcomes. This could be explained by the fact that while active white matter lesions are pathological substrates for relapses, MS progression is driven by mechanisms converging across immunopatterns, regardless of pathogenic mechanisms driving the acute demyelinated plaque.

Keyphrases

mass spectrometry
multiple sclerosis
ms ms
white matter
high resolution
liver failure
single cell
metabolic syndrome
weight loss
mechanical ventilation