Two Onnamide Analogs from the Marine Sponge Theonella conica : Evaluation of Geometric Effects in the Polyene Systems on Biological Activity.

Fumiaki Nakamura Hitoshi KurumizakaNobuhiro FusetaniYoichi Nakao

Published in: Molecules (Basel, Switzerland) (2023)

Two previously unreported onnamide analogs, 2 Z - and 6 Z -onnamides A ( 1 and 2 ), were isolated from the marine sponge Theonella conica collected at Amami-Oshima Is., Kagoshima Prefecture, Japan. Structures of compounds 1 and 2 were elucidated by spectral analysis. Structure-activity relationships (SARs) for effects on histone modifications and cytotoxicity against HeLa and P388 cells were characterized. The geometry in the polyene systems of onnamides affected the histone modification levels and cytotoxicity.

Keyphrases

cell cycle arrest
induced apoptosis
dna methylation
molecular docking
optical coherence tomography
high resolution
oxidative stress
pi k akt
endoplasmic reticulum stress
signaling pathway
gene expression
computed tomography
molecular dynamics simulations
dual energy