Frequent platelet donation is associated with lymphopenia and risk of infections: A nationwide cohort study.
Jingcheng ZhaoErin GabrielRut NordaPetter HöglundLindsey BadenBeatrice A DiedrichPer MaritsSara L EnokssonJohn M GansnerRichard Max KaufmanPaul W DickmanGustaf EdgrenPublished in: Transfusion (2020)
Frequent plateletpheresis donation using an LRS chamber was associated with CD4+ T-cell lymphopenia and an increased risk of infections. These findings suggest a need to monitor T-lymphocyte counts in frequent platelet donors and to conduct future investigations of long-term donor health and for regulators to consider steps to mitigate lymphodepletion in donors.