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Frequent platelet donation is associated with lymphopenia and risk of infections: A nationwide cohort study.

Jingcheng ZhaoErin GabrielRut NordaPetter HöglundLindsey BadenBeatrice A DiedrichPer MaritsSara L EnokssonJohn M GansnerRichard Max KaufmanPaul W DickmanGustaf Edgren
Published in: Transfusion (2020)
Frequent plateletpheresis donation using an LRS chamber was associated with CD4+ T-cell lymphopenia and an increased risk of infections. These findings suggest a need to monitor T-lymphocyte counts in frequent platelet donors and to conduct future investigations of long-term donor health and for regulators to consider steps to mitigate lymphodepletion in donors.
Keyphrases
  • healthcare
  • public health
  • peripheral blood
  • mental health
  • kidney transplantation
  • transcription factor
  • health information
  • current status
  • health promotion