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Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system.

Javier Águila-RosasTomás Quirino-BarredaGerardo Leyva-GómezEduardo González-ZamoraIlich A IbarraEnrique Lima
Published in: RSC advances (2020)
Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal-organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. The presence of zinc plays a significant role to the modulation of sulfadiazine-MOF interactions. Release of sulfadiazine from sulfadiazine@MOFs was monitored in vitro and ex vivo conditions. A kinetic release model is proposed for in vitro sulfadiazine release. Remarkably, the materials did not show cytotoxicity against eukaryote cells.
Keyphrases
  • metal organic framework
  • induced apoptosis
  • drug delivery
  • solid phase extraction
  • mass spectrometry
  • cell death
  • wound healing
  • cell cycle arrest