CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer.

Moran YangJiaqi LuGuodong ZhangYiying WangMengdi HeQing XuCongjian XuHaiou Liu

Published in: Journal for immunotherapy of cancer (2021)

These data define a critical role of CXCL13 in shaping antitumor microenvironment by facilitating the maintenance of CXCR5+CD8+ T cells in TLSs and support a clinical investigation for a combination of CXCL13 and PD-1 blockade therapy in HGSC.

Keyphrases

high grade
low grade
stem cells
dna damage
bone marrow
machine learning
cell proliferation