Platelets contribute to disease severity in COVID-19.

Tessa J BarrettSeda BilalogluMacintosh CornwellHannah M BurgessVitor W VirginioKamelia DrenkovaHomam IbrahimEugene YuriditskyYin AphinyanaphongsMark LifshitzFeng Xia LiangJulie AlejoGrace SmithStefania PittalugaAmy V RapkiewiczJun WangCamelia Iancu-RubinIan MohrKelly RugglesKenneth A StaplefordJudith HochmanJeffrey S Berger

Published in: Journal of thrombosis and haemostasis : JTH (2021)

Platelet count, size, and maturity associate with increased critical illness and all-cause mortality among hospitalized COVID-19 patients. Profiling tissues and blood from COVID-19 patients revealed that SARS-CoV-2 virions enter megakaryocytes and platelets and associate with alterations to the platelet transcriptome and activation profile.

Keyphrases

sars cov
single cell
respiratory syndrome coronavirus
rna seq
gene expression
red blood cell
coronavirus disease