SJPedPanel: A pan-cancer gene panel for childhood malignancies.

Pandurang Kolekar Vidya BalagopalLi DongYanling LiuScott FoyQuang TranHeather L MulderAnna Lw HuskeyEmily PlylerZhikai LiangJingqun MaJoy NakitandweJiali GuJamie MaciaszekDebbie Payne-TurnerSaradhi MallampatiLu WangElizabeth StewartJohn EastonJeffery M Klco Xiaotu Ma

Published in: medRxiv : the preprint server for health sciences (2023)

Overall, our gene panel enables the detection of clinically relevant genetic alterations including rearrangements responsible for subtype-defining fusions for childhood cancers by targeted sequencing of ∼0.15% of human genome. Our panel will significantly enhance the analysis of specimens with low tumor burdens for cancer monitoring and early detection.

Keyphrases

childhood cancer
genome wide
papillary thyroid
copy number
squamous cell
endothelial cells
young adults
early life
lymph node metastasis
gene expression
genome wide identification
loop mediated isothermal amplification
induced pluripotent stem cells
ultrasound guided