High-Frequency Spinal Stimulation Suppresses Microglial Kaiso-P2X7 Receptor Axis-Induced Inflammation to Alleviate Neuropathic Pain in Rats.
Jing YuStanley WongZhinan LinZhiming ShanChaoyang FanZhengyuan XiaMartin C H CheungXiaowei ZhuJessica Aijia LiuChi Wai CheungPublished in: Annals of neurology (2024)
HF10 SCS could improve the immunopathologic state in the SDH, extending its benefits beyond symptom relief. Targeting the Kaiso-P2X7R axis may enhance Con SCS therapy and offer a new strategy for pain management. ANN NEUROL 2024.
Keyphrases
- neuropathic pain
- high frequency
- pain management
- spinal cord
- transcranial magnetic stimulation
- spinal cord injury
- chronic pain
- oxidative stress
- diabetic rats
- high glucose
- signaling pathway
- stem cells
- inflammatory response
- atrial fibrillation
- bone marrow
- acute heart failure
- lipopolysaccharide induced
- smoking cessation
- cell therapy
- mesenchymal stem cells
- patient reported