Determination of rosmarinic acid and its N-substituted analog A1 in rat plasma using high-performance liquid chromatography-tandem mass spectrometry and its application in pharmacokinetics.
Shujie FuQinglang ZhangShiyu ZhangWeizhe JiangMinjie JiangPublished in: Rapid communications in mass spectrometry : RCM (2023)
The liquid chromatography-tandem mass spectrometry method developed in this study offers a rapid, sensitive, and alternative approach for the accurate quantification and identification of RA and A1 in vivo. The findings serve as a significant foundation for evaluating the clinical applications of the medicine.
Keyphrases
- liquid chromatography tandem mass spectrometry
- solid phase extraction
- simultaneous determination
- ms ms
- molecularly imprinted
- rheumatoid arthritis
- liquid chromatography
- tandem mass spectrometry
- molecular docking
- disease activity
- systemic sclerosis
- systemic lupus erythematosus
- mass spectrometry
- interstitial lung disease
- quantum dots