Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.
Paula DlugoszMagdalena TeuflMaximilian SchwabKatharina Eva KohlJohannes NimpfPublished in: International journal of molecular sciences (2021)
Disabled 1 (Dab1) is an adapter protein for very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) and an integral component of the Reelin pathway which orchestrates neuronal layering during embryonic brain development. Activation of Dab1 is induced by binding of Reelin to ApoER2 and VLDLR and phosphorylation of Dab1 mediated by Src family kinases. Here we show that Dab1 also acts as an adaptor for epidermal growth factor receptor (EGFR) and can be phosphorylated by epidermal growth factor (EGF) binding to EGFR. Phosphorylation of Dab1 depends on the kinase activity of EGFR constituting a signal pathway independent of Reelin and its receptors.
Keyphrases
- epidermal growth factor receptor
- tyrosine kinase
- growth factor
- advanced non small cell lung cancer
- low density lipoprotein
- signaling pathway
- protein kinase
- binding protein
- small cell lung cancer
- white matter
- epithelial mesenchymal transition
- multiple sclerosis
- wound healing
- amino acid
- small molecule
- functional connectivity