Association of markers of inflammation, the kynurenine pathway and B vitamins with age and mortality, and a signature of inflammaging.
Pierre-Antoine DuguéAllison M HodgeArve UlvikPer M UelandØivind MidttunSabina RinaldiRobert J MacinnisSherly X LiKlaus MeyerAnne-Sophie NavionisLeon FlickerGianluca SeveriDallas R EnglishPaolo VineisGrethe S TellMelissa C SoutheyRoger L MilneGraham G GilesPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2021)
Our study highlights the key role of the kynurenine pathway and vitamin B6 catabolism in aging, along with other well-established inflammation-related markers. A signature of inflammaging based on ten markers was strongly associated with mortality.