Nickel-Catalyzed Enantioselective Reductive Conjugate Arylation and Heteroarylation via an Elementary Mechanism of 1,4-Addition.

Luoqiang ZhangMengxin ZhaoMaoping PuZhaoming MaJingsong ZhouCaiyou Chen Yun-Dong Wu Yonggui Robin Chi Jianrong Steve Zhou

Published in: Journal of the American Chemical Society (2022)

A nickel complex of isoquinox promoted enantioselective conjugate arylation and heteroarylation of enones using aryl and heteroaryl halides directly. The reaction was successfully applied to stereoselective syntheses of ar -turmerone, chiral fragments of (+)-tolterodine and AZD5672. Mechanistically, experiments and calculations supported that an arylnickel(I) complex inserted to enones via an elementary 1,4-addition.

Keyphrases

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