GATA-3 Dependent Gene Transcription is Impaired upon HDAC Inhibition.
Xiangrong GengChenguang WangSuhaib AbdelrahmanThilini PereraBadeia SaedYing Samuel HuAshley WolfeJohn C ReneauCarlos A Murga-ZamalloaRyan A WilcoxPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Beyond shedding new light on the mechanism of action associated with HDACi in CTCL, these findings have significant implications for their use, both as single agents and in combination with other novel agents, in GATA-3 driven lymphoproliferative neoplasms.