Daptomycin Exposure as a Risk Factor for Daptomycin-Induced Eosinophilic Pneumonia and Muscular Toxicity.
Romain GarreauTruong-Thanh PhamLaurent BourguignonAurélien MilletFrançois ParantDavid BussyMarine DesevreVictor FranchiTristan FerrySylvain GoutellePublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)
We identified common determinants of DIEP and myotoxicity in patients with BJI. Because the risk of AEs was associated with daptomycin exposure, daptomycin TDM and model-informed precision dosing may help optimize the efficacy and safety of daptomycin treatment in this setting. A target AUC24h range of 666 to 939 mg/h/L is suggested.