Diagnostic significance of LncRNA MIAT in periodontitis and the molecular mechanisms influencing periodontal ligament fibroblasts via the miR-204-5p/DKK1 axis.

Yu RenJiwen ZhengYang CaoYu ZhuZhuo LingZhiqiang ZhangMingke Huang

Published in: Archives of oral biology (2024)

MIAT may act as a promising biomarker for periodontitis. It modulates apoptosis, inflammation, and osteogenic differentiation of PDLFs by focusing on the miR-204-5p/DKK1 axis, indicating its potential as a new therapeutic target for treating periodontitis.

Keyphrases

oxidative stress
endoplasmic reticulum stress
cell death
long non coding rna
cell cycle arrest