The Prognostic and Diagnostic Value of [ 18 F]FDG PET/CT in Untreated Laryngeal Carcinoma.
Akram N Al-IbraheemAhmed Saad AbdlkadirDhuha Al-AdhamiTaher Abu HejlehAsem MansourIssa MohamadMalik E JuweidUla Al-RasheedNabeela Al-HajajDima Abu LabanEnrique Estrada-LobatoOmar SarairehPublished in: Journal of clinical medicine (2023)
This study aims to determine the diagnostic accuracy of staging PET/CT and neck MRI in patients with laryngeal carcinoma and to assess the value of PET/CT in predicting progression-free survival (PFS) and overall survival (OS). Sixty-eight patients who had both modalities performed before treatment between 2014 and 2021 were included in this study. The sensitivity and specificity of PET/CT and MRI were evaluated. PET/CT had 93.8% sensitivity, 58.3% specificity, and 75% accuracy for nodal metastasis, whereas MRI had 68.8%, 61.1%, and 64.7% accuracy, respectively. At a median follow-up of 51 months, 23 patients had developed disease progression and 17 patients had died. Univariate-survival analysis revealed all utilized PET parameters as significant prognostic factors for OS and PFS ( p -value < 0.03 each). In multivariate analysis, metabolic-tumor volume (MTV) and total lesion glycolysis (TLG) predicted better PFS ( p -value < 0.05 each). In conclusion, PET/CT improves the accuracy of nodal staging in laryngeal carcinoma over neck MRI and adds to the prognostication of survival outcomes through the use of several PET metrics.
Keyphrases
- pet ct
- prognostic factors
- free survival
- positron emission tomography
- magnetic resonance imaging
- end stage renal disease
- contrast enhanced
- newly diagnosed
- chronic kidney disease
- lymph node
- diffusion weighted imaging
- peritoneal dialysis
- magnetic resonance
- squamous cell carcinoma
- neoadjuvant chemotherapy
- single cell
- patient reported
- pet imaging