Fanca deficiency is associated with alterations in osteoclastogenesis that are rescued by TNFα.

Alessia OppezzoLovely MonneyHenri KilianLofti SlimaniFrédérique Maczkowiak-ChartoisFilippo Rosselli

Published in: Cell & bioscience (2023)

Overall, our results highlight an unappreciated role of Fanca in OC differentiation that is potentially circumvented in vivo by the presence of OBs and TNFα in the BM niche.

Keyphrases

rheumatoid arthritis
replacement therapy
lps induced
inflammatory response
bone loss